Nearly half the number of seats were uncontested and PAP was one seat away from forming the government on nomination day. This GE saw the debut of the newly formed SDP that was to wax and wane in years to come. The school streaming system and former PAP Minister Phey Yew Kok's embezzlement of trade union funds became the main election issues. Parliament announced his Boon Teck seat vacated on 2 April 1980 after he jumped bail and fled the country but no by-election was called as a GE was impending. The Electoral Boundaries Delineation Committee report, submitted to the government on 2 June 1980, was tabled in a bill on 25 June and passed on 29 July the same year. Nine wards were carved out and three were dissolved, namely Farrer Park, Geylang East and Upper Serangoon. For the first time, no independent candidates emerged. Election deposit increased for the second consecutive time but less drastically this time. PAP achieved the fourth consecutive and final clean sweep of all Parliament seats and its share of votes was the second highest following the 1968 GE.

4th Parliament dissolution: 5 December 1980 [Fri]
Nomination day: 13 December 1980 [Sat]
Polling day: 23 December 1980 [Tue]
5th Parliament convention: 3 February 1981 [Tue]

Electorate: 1,290,426
Walkover voters: 605,285 (46.9%)
Eligible voters: 685,141 (53.1%)
Voter turnout: 654,295 (95.5%)

Election deposit: $1,500 (+$300)

Alexandra Buona Vista Jurong Leng Kee Serangoon Gardens
Aljunied Cairnhill Kaki Bukit MacPherson Siglap
Ang Mo Kio Changi Kallang Marine Parade Tampines
Anson Cheng San Kampong Chai Chee Moulmein Tanah Merah
Ayer Rajah Chong Boon Kampong Glam Mountbatten Tanglin
Bedok Chua Chu Kang Kampong Kembangan Nee Soon Tanjong Pagar
Boon Lay Clementi Kampong Ubi Pasir Panjang Telok Ayer
Boon Teck Delta Katong Paya Lebar Telok Blangah
Braddell Heights Geylang Serai Kebun Baru Potong Pasir Thomson
Brickworks Geylang West Khe Bong Punggol Tiong Bahru
Bukit Batok Havelock Kim Keat Queenstown Toa Payoh
Bukit Ho Swee Henderson Kim Seng Radin Mas Ulu Pandan
Bukit Merah Jalan Besar Kolam Ayer River Valley West Coast
Bukit Panjang Jalan Kayu Kreta Ayer Rochore Whampoa
Bukit Timah Joo Chiat Kuo Chuan Sembawang Yio Chu Kang
Total seats = 75